American Atheists holds National Conventions to bring together members of the atheist community from across the country. Past convention speakers include Ayaan Hirsi Ali, Richard Dawkins, Christopher Hitchens, Dr. Sian Proctor, Chris Kluwe, Greta Christina, Hugh Laurie, AZ State Rep. Athena Salman, activist Jim Obergefell, and many others. With educational presentations, social events, comedy and game nights, training workshops, exhibits, and opportunities for networking, conventions are the highlight of the year for hundreds of American atheists.

American Atheists conventions have traditionally been held over Easter weekend in cities including Philadelphia, Phoenix, Atlanta, Cincinnati, Salt Lake City, Memphis, Austin, Denver, Oklahoma City, Des Moines, and others. In 2017, American Atheists celebrated the first total solar eclipse in the continental United States in decades by hosting the convention in North Charleston, SC, in August.